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June 7, 2012Journal of Cardiovascular Medicine

Coronary plaque quantification and composition in asymptomatic patients with type II diabetes mellitus

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Why the study?

Does type II diabetes mellitus affect coronary plaque extent and morphology in asymptomatic patients without ischemic heart disease?

Population

199 asymptomatic patients with no history of ischemic heart disease, comprising 102 patients with type II…

Comparison

Type II diabetes mellitus (exposure) vs Patients without diabetes (controls)

Design

Cross-sectional

Authors

OMOlivia ManfriniVRVincenzo RussoACA Ciavarella

Discussion

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Overview

May indicate diabetes-linked plaque features in asymptomatic patients; hypothesis-generating and should not yet alter practice.

Structured PICO

Does type II diabetes mellitus affect coronary plaque extent and morphology in asymptomatic patients without ischemic heart disease?

P
Population
199 asymptomatic patients with no history of ischemic heart disease, comprising 102 patients with type II diabetes mellitus and 97 patients without diabetes as controls.
I
Intervention
Type II diabetes mellitus (exposure)
C
Comparator
Patients without diabetes (controls)
O
Outcome
Extent and morphology of coronary lesions, including plaque density, plaque volume, and arterial remodeling evaluated by multidetector computed tomography (MDCT).surrogate

Asymptomatic patients with type II diabetes mellitus exhibit more extensive coronary plaque burden with impaired adaptive remodeling and higher tissue density compared to non-diabetic individuals.

Cite This Study

Manfrini et al. (2012) studied this question.

synapsesocial.com/papers/6a720ed5ac440176ef2a7e25https://doi.org/10.2459/jcm.0b013e32835593f9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Noninvasive Assessment of Plaque Characteristics With Multislice Computed Tomography Coronary Angiography in Symptomatic Diabetic Patients2007 · 73 citations
  2. 2Differences in Atherosclerotic Plaque Burden and Morphology Between Type 1 and 2 Diabetes as Assessed by Multislice Computed Tomography2009 · 65 citations
  3. 3The frequency of coronary artery atherosclerotic plaques in patients with newly diagnosed type 2 diabetes mellitus2024
  4. 4Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes2007 · 163 citations
  5. 5Plaque characteristics of nonobstructive coronary lesions in diabetic patients: an intravascular ultrasound virtual histology analysis2010 · 6 citations