Why the study?
Does diabetes mellitus associate with distinct plaque composition and morphology in nonobstructive coronary lesions compared to nondiabetic patients?
Population
41 patients with proximally located angiographically nonobstructive coronary lesions
Comparison
Diabetes mellitus vs Nondiabetic patients
Design
Cohort
Key result
In patients with nonobstructive coronary lesions, diabetes mellitus was an independent predictor of thin-cap fibroatheromas at the minimal lumen area site (OR 9.43; 95% CI 1.06-84.04; P=0.04).
Authors
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Diabetes associated with vulnerable plaques in nonobstructive lesions; hypothesis-generating and should not yet change practice.
Observational (n=41)
Does diabetes mellitus associate with distinct plaque composition and morphology in nonobstructive coronary lesions compared to nondiabetic patients?
Odds Ratio: 9.43 (95% CI 1.06–84.04)
Absolute Event Rate: 92% vs 54%
p-value: p=0.04
Diabetic patients exhibit more vulnerable plaque characteristics, including higher necrotic core percentages and more frequent thin-cap fibroatheromas, in nonobstructive coronary lesions compared to nondiabetics.
Abdel‐Wahab et al. (2010) conducted an observational in Nonobstructive coronary lesions (n=41). Diabetes mellitus vs. Nondiabetic patients was evaluated on IVUS-derived thin-cap fibroatheromas (IDTCFAs) at the minimal lumen area site (OR 9.43, 95% CI 1.06-84.04, p=0.04). In patients with nonobstructive coronary lesions, diabetes mellitus was an independent predictor of thin-cap fibroatheromas at the minimal lumen area site (OR 9.43; 95% CI 1.06-84.04; P=0.04).
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