Why the study?
Encountering a neonate born with congenital gangrene from thromboembolic events is extremely rare, warranting discussion of its etiology, diagnosis, and treatment.
Congenital gangrene due to spontaneous arterial thrombosis is a rare but devastating condition in neonates that may require amputation when limb salvage is precluded.
Neonatal spontaneous iliac thrombosis risks unsalvageable limb loss; extends recognition of infantile thromboembolism while leaving optimal management undefined.
CASE: A full-term neonate presented with right lower extremity ischemia at birth because of spontaneous thrombosis of the right common iliac artery. He was initially managed with supportive treatment, anticoagulation, and dressings; however, advanced gangrenous changes precluded salvage of the ischemic limb. A guillotine amputation was performed at day 15 of life, and the stump went on to heal well by secondary intention. CONCLUSION: Thromboembolic events occurring in infancy are well-recognized phenomena; however, it is far rarer to encounter a neonate born with "congenital gangrene". We discuss the etiology, approach to diagnosis, and treatment of this rare but devastating condition.
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Vaidya et al. (2021) studied this question.
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