Neonatal extremity gangrene from intrauterine embolization should be managed conservatively, delaying amputation to allow the line of demarcation to migrate distally.
May support conservative timing in neonatal gangrene; leaves open need for prospective validation.
A neonate with extremity gangrene resulting from intrauterine embolization of infarcted placental substances is discussed. This rare clinical entity is thought to be most commonly a manifestation of embolic phenomenon during maturation of the neonatal circulatory system. Management of neonatal gangrene is conservative, delaying amputation as long as possible since the line of demarcation tends to migrate distally. Evidence of multiple emboli should be carefully sought prior to definitive treatment.
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Carr et al. (1996) studied this question.
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