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February 11, 2005Journal of Biological ChemistryOpen Access

Simvastatin Attenuates Expression of Cytokine-inducible Nitric-oxide Synthase in Embryonic Cardiac Myoblasts

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Why the study?

Does simvastatin reduce iNOS expression and NO synthesis in cytokine-stimulated embryonic cardiac myoblasts?

Population

Rat H9c2 cardiac embryonic myoblasts stimulated with proinflammatory cytokines

Comparison

Simvastatin vs Cytokine-stimulated cells without simvastatin

Design

Preclinical

Authors

RMRosalinda MadonnaUniversity of PisaPNPericle Di NapoliUniversity of Chieti-PescaraMMMarika MassaroIstituto di Fisiologia Clinica

Discussion

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Implication

Should not change practice; hypothesis-generating for statin effects on cardiac myoblast inflammation in vivo.

Structured PICO

Does simvastatin reduce iNOS expression and NO synthesis in cytokine-stimulated embryonic cardiac myoblasts?

P
Population
Rat H9c2 cardiac embryonic myoblasts stimulated with proinflammatory cytokines (interleukin-1 or tumor necrosis factor)
I
Intervention
Simvastatin
C
Comparator
Cytokine-stimulated cells without simvastatin
O
Outcome
Expression of inducible nitric-oxide synthase (iNOS) mRNA and protein, and NO synthesissurrogate

Simvastatin attenuates iNOS expression and NO synthesis in cytokine-stimulated embryonic cardiac myoblasts, suggesting a potential protective mechanism for cardiac myocyte progenitors in ischemic hearts.

Cite This Study

Madonna et al. (2005) studied this question.

synapsesocial.com/papers/6a72106f26a7f98052de1e04https://doi.org/10.1074/jbc.m411859200

Topics

Statin therapy
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