August 1, 2000Arteriosclerosis Thrombosis and Vascular Biology

Periadventitial Inducible Nitric Oxide Synthase Expression and Intimal Thickening

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Why the study?

Does local inhibition of iNOS affect intimal thickness in a rabbit carotid artery collar model?

Structured PICO

Does local inhibition of iNOS affect intimal thickness in a rabbit carotid artery collar model?

Population

Rabbit carotid artery model with silicone collar-induced intimal thickening (n=12 for local delivery experiment)

Intervention

Local delivery of iNOS inhibitor L-N(6)-(1-iminoethyl)-lysine-HCl (L-NIL, 10 mmol/L) via osmotic minipumps (5 microL/h for 14 days) or local infusion of oxidized LDL (ox-LDL) for 14 days

Comparator

Local delivery of saline, sham-operated, or naïve arteries

Outcome

Intimal thickness and localization/expression of iNOSsurrogate

In a rabbit model, iNOS is expressed in periadventitial tissue and counteracts the progression of intimal thickening, as its inhibition doubles intimal thickness.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Suggests periadventitial iNOS protects against intimal hyperplasia in rabbits; hypothesis-generating with no immediate clinical implications.

Cite This Study

Meyer et al. (2000) studied this question.

synapsesocial.com/papers/6a72114eb5c1fe5ca9dff09d https://doi.org/10.1161/01.atv.20.8.1896

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Implication

Suggests periadventitial iNOS protects against intimal hyperplasia in rabbits; hypothesis-generating with no immediate clinical implications.

Periadventitial Inducible Nitric Oxide Synthase Expression and Intimal Thickening

Structured PICO

Discussion

Implication

Cite This Study

Periadventitial Inducible Nitric Oxide Synthase Expression and Intimal Thickening

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider