Population
Normal and balloon-injured rat aortas (adult and embryo), and cultured rat aortic smooth muscle cells
Comparison
Balloon injury vs Normal (uninjured) rat aortas
Design
Preclinical
Follow-up
8 or 20 days
Authors
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P2Y2 expression after arterial injury may contribute to hyperplasia; animal data leave open any role in human restenosis.
Strong expression of the P2Y2 purinoceptor in the neointima of injured arteries suggests a potential role for extracellular nucleotides in intimal hyperplasia and restenosis.
Seye et al. (1997) studied this question.
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