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We utilized various mouse models of IBD to demonstrate that TL1A expression on the surface of DCs is increased in inflamed intestines. Moreover, Tl1a−/− naive CD4+ T cells exhibited impaired ability for Th1 or Th17 differentiation ex vivo, and ...The binding of tumor necrosis factor–like cytokine 1A (TL1A) to death receptor 3 (DR3) plays an important role in the interaction between dendritic cells (DCs) and T cells and contributes to intestinal inflammation development. However, the mechanism by ...
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Caspari et al. (1948) studied this question.
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