Synthesis, spectroscopic characterization, and antibacterial assays in vitro of a new platinum(II) complex with methionine sulfoxide

A new platinum(II) complex with methionine sulfoxide was synthesized and characterized by chemical and spectroscopic techniques. Elemental analyses, mass spectrometric measurements (electrospray ionization quadrupole time-of-flight mass spectrometry), and thermal analyses of the solid compound fit the composition [(C5H10NO3S)Pt(µ-Cl)2Pt(C5H10NO3S)] · 2.5H2O. Infrared spectroscopic data indicate coordination of the ligand to Pt(II) through the nitrogen of NH2 and the sulfur of the S=O group. 1H-15N nuclear magnetic resonance spectroscopic data confirm nitrogen coordination. Antibacterial activities were evaluated by antibiogram assays using the disc diffusion method. The platinum(II) complex showed antibacterial activity against Gram-negative Pseudomonas aeruginosa bacterial cells.