Population
N-cadherin conditional knock-out (N-cad CKO) mice and wild type mice (cardiomyocytes)
Comparison
Cardiac-specific deletion of N-cadherin vs Wild type mice
Design
Preclinical
Authors
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Animal data link N-cadherin loss to Kv remodeling and APD changes; leaves open relevance to human arrhythmogenesis.
Cortactin is required for N-cadherin-mediated enhancement of Kv1.5 channel activity, suggesting aberrant Kv1.5 function contributes to arrhythmogenesis in N-cadherin deficiency.
Cheng et al. (2011) studied this question.
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