Why the study?
Does excitation of afferent cardiac sympathetic nerve fibers induce tachypnea in anesthetized vagotomized dogs?
Does excitation of afferent cardiac sympathetic nerve fibers induce tachypnea in anesthetized vagotomized dogs?
Excitation of afferent cardiac sympathetic nerve fibers can produce tachypnea, demonstrating a physiological link between cardiac sympathetic afferents and respiratory regulation.
Indicates sympathetic afferent-respiratory coupling in dogs; leaves open relevance to human ischemia or HF.
The role of afferent cardiac sympathetic nerve fibers in the regulation of respiration has been examined. Application of potassium chloride or lactic acid solutions to the left ventricular surface of anesthetized vagotomized dogs resulted in a decrease in the manimum firing rate and shortening in period duration of firing of phrenic nerves. Also, application of the agents caused a decrease in amplitude and an increase in rate of respiratory thoracic movements. The same changes in phrenic nerve activity and respiratory movements were produced by coronary artery occlusion and centrifugal electrical stimulation of the left inferior cardiac nerves. The results indicate tachypnea that can be produced by excitation of afferent cardiac sympathetic nerve fibers.
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Yuto Uchida (1976) studied this question.
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