August 1, 1983AJP Regulatory Integrative and Comparative Physiology

Widespread neural excitation initiated from cardiac spinal afferent nerves

View Full Paper

Ask AI

Bookmark

Population

Anesthetized, vagotomized, baroreceptor-denervated cats

Design

Preclinical

Authors

LWLynne C. WeaverWestern University RMR. L. MecklerThe University of Queensland HFHildburg FryFederal Institute for Risk Assessment

Discussion

Member takes

Implication

Supports spinal-level mediation of cardiac afferent responses; hypothesis-generating for human cardiac pain or ischemia syndromes.

Structured PICO

Population

Anesthetized, vagotomized, baroreceptor-denervated cats

Intervention

Stimulation of cardiac sympathetic spinal afferent neurons by the noxious substance bradykinin (as well as electrical and chemical stimulation)

Outcome

Excitation of sympathetic nerves (cardiac, renal, splenic, gastrohepatic, adrenal, and deep peroneal), phrenic nerves, and electroencephalogram desynchronizationsurrogate

Noxious stimulation of cardiac sympathetic afferent nerves causes widespread neural excitation that does not require supramedullary mediation, providing a physiological basis for systemic responses to cardiac pain or stress.

Cite This Study

Weaver et al. (1983) studied this question.

synapsesocial.com/papers/6a913ee0d613fa9f3b465b52 https://doi.org/10.1152/ajpregu.1983.245.2.r241

View Full Paper

Ask AI

Bookmark

Widespread neural excitation initiated from cardiac spinal afferent nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Widespread neural excitation initiated from cardiac spinal afferent nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider