What question did this study set out to answer?

To determine how arterial baroreceptor activation affects the A- and C-components of somato-cardiac sympathetic reflex discharges.

January 1, 1998The Japanese Journal of PhysiologyOpen Access

Excitation of Baroreceptors Depresses A- and C-Components of the Somato-Cardiac Sympathetic Reflex in Anesthetized Rats.

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Population

Urethane-anesthetized, vagotomized, and artificially ventilated rats

Comparison

Baroreceptor activation via sudden increase in… vs Bilateral sino-aortic denervation

Design

Preclinical

Authors

WLWei Min LiSichuan University XLXia LiuLinyi People's Hospital ASAkio SatoTohoku Institute of Technology

Discussion

Member takes

Implication

Does not support clinical practice changes; leaves open baroreflex modulation of sympathetic reflexes pending translational studies.

Key Points

To determine how arterial baroreceptor activation affects the A- and C-components of somato-cardiac sympathetic reflex discharges.
Examined urethane-anesthetized, vagotomized, and artificially ventilated rats.
Delivered single electrical shocks to myelinated A-fibers and unmyelinated C-fibers of the tibial nerve to record cardiac sympathetic reflex discharges.
Elevated mean arterial pressure via intravenous phenylephrine (50 μg/kg) before and after bilateral sino-aortic denervation.
Phenylephrine elevation of arterial pressure to ~150 mmHg depressed the A- and C-reflex components to 47 ± 5.4% and 37 ± 7.7% of control values, respectively, when aortic and carotid sinus nerves were intact.
Bilateral sino-aortic denervation completely abolished the arterial pressure-induced depression of both reflex components.

Structured PICO

Population

Urethane-anesthetized, vagotomized, and artificially ventilated rats

Intervention

Baroreceptor activation via sudden increase in mean arterial blood pressure to about 150 mmHg induced by I.V. injection of phenylephrine (50 micro/kg)

Comparator

Bilateral sino-aortic denervation

Outcome

A- and C-components of the somato-cardiac sympathetic reflex dischargessurrogate

Baroreceptor afferent signals from the aortic and carotid sinus nerves inhibit both A- and C-components of excitatory somato-cardiac sympathetic reflex discharges in rats.

Cite This Study

Li et al. (1998) studied this question.

synapsesocial.com/papers/6a8542d23cde6ee03eb2ea88 https://doi.org/10.2170/jjphysiol.48.261

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Excitation of Baroreceptors Depresses A- and C-Components of the Somato-Cardiac Sympathetic Reflex in Anesthetized Rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Excitation of Baroreceptors Depresses A- and C-Components of the Somato-Cardiac Sympathetic Reflex in Anesthetized Rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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