Why the study?
Does electrical stimulation of the vagus nerve alter sympathetic nerve activity and baroreflex sensitivity via the parabrachial nucleus in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats anesthetized with thiobutabarbital sodium (50 mg/kg)
Comparison
Electrical stimulation of the cervical vagus or… vs Microinjection of lidocaine into the…
Design
Preclinical
Authors
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Mechanistic insight into vagal effects on sympathetic activity in rats; leaves open translation to clinical neuromodulation.
Does electrical stimulation of the vagus nerve alter sympathetic nerve activity and baroreflex sensitivity via the parabrachial nucleus in male Sprague-Dawley rats?
Activation of cardiac, pulmonary, or general gastric afferents increases sympathetic output and decreases baroreflex sensitivity via a pathway involving the parabrachial nucleus in a rat model.
Saleh et al. (1999) studied this question.
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