Key result
Guanethidine and methyldopa effectively lower blood pressure in patients with hypertension.
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Guanethidine and methyldopa are commonly used drugs in the treatment of hypertension, but the manner in which they act on the circulation to lower the blood pressure remains controversial. Systemic arterial pressure depends on both cardiac output and total peripheral resistance, and a reduction in either of these can result in a fall of pressure. Guanethidine has been said by some to act principally by lowering peripheral resistance (Lichtlen, Schaub, and Biihlmann, 1960; Roy, Mathur, and Bhatia, 1961; Taylor et al., 1962), while others have considered a fall in cardiac output to be the most important factor (Richardson et al., 1960; Rokseth et al., 1962). Dollery, Emslie- Smith, and Shillingford (1961) thought the postural hypotensive effect was to some extent due to a failure of vasoconstriction to compensate for the normal reduction in cardiac output on standing.
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Chamberlain et al. (1964) studied Hypertension. Guanethidine and methyldopa was evaluated on Haemodynamic parameters (cardiac output and total peripheral resistance). Guanethidine and methyldopa lower blood pressure in hypertension, though the abstract snippet reports no quantitative haemodynamic results.
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