Why the study?
Mitophagy is essential for normal cardiac function, but the effect of diabetes on cardiac mitophagy flux remains unclear.
Population
Diabetic and nondiabetic mice, and cardiomyocytes
Comparison
Diabetic vs nondiabetic mice
Design
Animal and cell study using a novel dual fluorescent mitophagy reporter
Authors
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Diabetes may impair cardiac mitophagy; leaves open its role in heart failure and need for targeted trials.
Mitophagy is impaired in the diabetic heart, suggesting that restoring mitophagy flux could be a potential therapeutic target to reduce diabetes-induced cardiac injury.
Kobayashi et al. (2020) studied this question.
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