November 2, 2013Cardiovascular DiabetologyOpen Access

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

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Population

Rat model of diabetic cardiomyopathy (DCM) and primary cardiomyocytes

Comparison

Knockdown of IRE1, ATF6, and PERK in… vs Comparison between different knockdowns and…

Design

Preclinical

Authors

Discussion

May identify PERK as primary target in diabetic cardiomyopathy; hypothesis-generating from myocyte models and leaves open clinical translation.

Population

Rat model of diabetic cardiomyopathy (DCM) and primary cardiomyocytes

Intervention

Knockdown of IRE1, ATF6, and PERK in high-glucose incubated cardiomyocytes

Comparator

Comparison between different knockdowns (ATF6, IRE1, PERK) and control

Outcome

Cardiomyocyte apoptosissurrogate

The PERK signaling pathway is the primary mediator of ROS-induced ER stress and subsequent cardiomyocyte apoptosis in diabetic cardiomyopathy.

Liu et al. (2013) studied this question.

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May identify PERK as primary target in diabetic cardiomyopathy; hypothesis-generating from myocyte models and leaves open clinical translation.