Rapid Fire - Basic Science 1

Phillip H. Lam; Daniel J. Dooley; Gregg C. Fonarow; Javed Butler; Deepak L. Bhatt; Gerasimos Filippatos; Prakash Deedwania; Daniel E. Forman; Michel White; Ross D. Fletcher; Cherinne Arundel; Marc R. Blackman; Chris Adamopoulos; Ioannis Kanonidis; Inmaculada Aban; Kanan Patel; Wilbert S. Aronow; Richard M. Allman; Stefan D. Anker; Bertram Pitt; Ali Ahmed

doi:10.1002/ejhf.937

Why the study?

Does target dose enalapril compared to below-target dose improve outcomes in patients with HFrEF?

Structured PICO

Does target dose enalapril compared to below-target dose improve outcomes in patients with HFrEF?

P

Population

2,569 patients with HFrEF (ejection fraction ≤35%) from the SOLVD Treatment trial

I

Intervention

Enalapril (target dose 20 mg/day or below-target dose 5-10 mg/day)

C

Comparator

Placebo (target dose 20 mg/day or below-target dose 5-10 mg/day)

O

Outcome

Combined endpoint of heart failure hospitalization or all-cause mortalitycomposite

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Implication

In patients with HFrEF, below-target doses of enalapril appear to provide similar clinical benefits to target doses, challenging the strict necessity of up-titration if not tolerated.

Abstract

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Discussion

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Cite This Study

Lam et al. (2014) studied this question.

synapsesocial.com/papers/6a721c2c660549caf2c67298 https://doi.org/10.1002/ejhf.937

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Rapid Fire - Basic Science 1

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Rapid Fire - Basic Science 1

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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