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January 1, 2019SAGE Open Medicine7 citationsOpen Access

Very low-density lipoprotein cholesterol is associated with extent and severity of coronary artery disease in patients with type 2 diabetes mellitus

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Why the study?

Is very low-density lipoprotein cholesterol associated with the extent and severity of coronary artery disease in patients with type 2 diabetes mellitus?

Population

410 coronary artery disease patients, comprising 205 with type 2 diabetes mellitus and 205 age-, gender- and…

Design

Case-control

Authors

AJAimei JiaWZWei ZengLYLiuqin Yu

Discussion

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Overview

VLDL-C may aid CAD risk stratification in T2DM; leaves open whether lowering it alters outcomes.

Structured PICO

Is very low-density lipoprotein cholesterol associated with the extent and severity of coronary artery disease in patients with type 2 diabetes mellitus?

P
Population
410 coronary artery disease patients, comprising 205 with type 2 diabetes mellitus and 205 age-, gender- and smoking-matched patients without type 2 diabetes mellitus.
O
Outcome
Severity of coronary artery disease assessed using Gensini scoring system, the number of diseased coronary arteries, and the extent of coronary stenosissurrogate

Elevated very low-density lipoprotein (VLDL) cholesterol is independently associated with greater angiographic severity and extent of coronary artery disease in patients with type 2 diabetes mellitus.

Limitations

  • Cannot determine causal role of VLDL in coronary artery disease
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Cite This Study

Jia et al. (2019) studied this question.

synapsesocial.com/papers/6a721c6435aa2c282ce31771https://doi.org/10.1177/2050312119871786
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