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July 11, 2024Frontiers in PsychiatryOpen Access

Efficacy and safety of pharmacogenomic-guided antidepressant prescribing in patients with depression: an umbrella review and updated meta-analysis

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Authors

KTKiflu Gebremicael TesfamicaelLZLijun ZhaoRFRubén Fernández‐Rodríguez

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Overview

Umbrella review and meta-analysis demonstrates increased remission rates in patients with depression, indicating that genetic profiling improves antidepressant selection.

Key Points

  • To evaluate the efficacy and safety of pharmacogenomics-guided antidepressant prescribing compared to standard treatment in patients diagnosed with depression.
  • Conducted an umbrella review and updated meta-analysis across PsycINFO, PubMed, Embase, and Cochrane databases (PROSPERO CRD42022321324).
  • Pooled randomized controlled trial data to calculate mean differences for continuous measures and risk ratios for noncontinuous outcomes.
  • Patients receiving pharmacogenomics-guided therapy were 41% to 78% more likely to achieve symptom remission compared to treatment-as-usual.
  • Guidance from pharmacogenomic testing increased the likelihood of clinical response to antidepressants by 20% to 49% relative to standard care.
  • The magnitude and statistical significance of treatment advantages varied widely across individual trials and specific pharmacogenomic testing panels.

Cite This Study

Tesfamicael et al. (2024) studied this question.

synapsesocial.com/papers/6a721f70abc331a85807b612https://doi.org/10.3389/fpsyt.2024.1276410
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