Key Points
- To investigate the relationship between body height and venous thromboembolism risk, focusing on sex differences.
- Prospective cohort study of 26,727 participants aged 25-96 from the Tromsø Study (Norway)
- Incident VTE events were recorded over a median follow-up of 12.5 years
- Multivariable hazard ratios adjusted for confounding factors were calculated.
- Men had a hazard ratio of 1.34 (95% CI: 1.09, 1.64) per 10 cm increase in height for VTE risk
- Men in the upper quartile (>181 cm) had a 1.99-fold increased risk of VTE (95% CI: 1.35, 2.92) compared to those in the lowest quartile (<173 cm)
- No significant association between body height and VTE risk was found in women (P = 0.2).
Structured PICO
Does body height increase the risk of venous thromboembolism in a general population?
PPopulation26,727 subjects aged 25-96 years from the general population participating in the Tromsø Study (Norway)
IInterventionBody height (analyzed per 10 cm increase and by quartiles)
CComparatorLower body height (e.g., lowest quartile <173 cm for men)
OOutcomeIncident venous thromboembolism (VTE) eventshard clinical
Body height is a sex-specific risk factor for venous thromboembolism, significantly increasing risk in men but not women.