Why the study?
What is the relationship between acute ischaemic stroke and plasma D-dimer levels in patients without VTE, and what is the diagnostic performance of D-dimer assays for VTE in this population?
What is the relationship between acute ischaemic stroke and plasma D-dimer levels in patients without VTE, and what is the diagnostic performance of D-dimer assays for VTE in this population?
D-dimer assays have 100% sensitivity but low specificity (30-34%) for excluding VTE in acute ischaemic stroke patients due to persistently elevated D-dimer levels from the stroke itself.
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D-dimer testing cannot exclude VTE in AIS; leaves open need for imaging or alternative markers given stroke-related elevations.
Kelly et al. (2003) studied this question.
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