Immunologic Reactions After Cortical Lesions in Rabbits

WHILE studying the Arthus reaction in monkey brain and using aluminum hydroxide as an adjuvant in combination with foreign proteins applied to the cortex, Kopeloff et al¹discovered that aluminum hydroxide alone could produce recurrent convulsive seizures. Although these authors became famous for this discovery, it is interesting to consider some of the observations made in relation to the use of immunological techniques in the study of experimental epilepsy. They reported that sensitization of the brain with a single foreign protein such as egg white (without adjuvant) placed on the brain of monkeys generally sensitized to egg white or egg white injected intravenously into animals in which egg white had been previously applied to the cortex, yielded acute seizures. These were defined as single attacks or a series of attacks which usually terminated within one week of onset. Kopeloff et al¹examined the sera of