Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol‐induced atherosclerosis
Why the study?
Does telmisartan, ramipril, or their combination improve endothelial function and reduce atherosclerosis in ApoE-/- mice on a cholesterol-rich diet?
Population
Wild-type (WT, C57/B6) and apolipoprotein-E-deficient (ApoE-/-) mice treated with a cholesterol-rich diet
Comparison
Telmisartan, ramipril, or the combination… vs Untreated ApoE-/- mice and WT animals
Design
Preclinical
Follow-up
8 weeks
Authors
Discussion
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Member takes
Implication
Does not support clinical adoption in atherosclerosis; leaves open translation of these murine findings to human endothelial function.
Structured PICO
Does telmisartan, ramipril, or their combination improve endothelial function and reduce atherosclerosis in ApoE-/- mice on a cholesterol-rich diet?
P
Population
Wild-type (WT, C57/B6) and apolipoprotein-E-deficient (ApoE-/-) mice treated with a cholesterol-rich diet
I
Intervention
Telmisartan (20 mg/kg/day), ramipril (2.5 mg/kg/day), or the combination thereof for 8 weeks
C
Comparator
Untreated ApoE-/- mice and WT animals
O
Outcome
Endothelial function in the aorta and corpus cavernosum, and atherosclerotic lesion sizesurrogate
In a murine model of atherosclerosis, telmisartan and ramipril similarly improved endothelial function and reduced atherosclerotic lesions via oxidative stress reduction, with no added benefit from their combination.
Cite This Study
Schlimmer et al. (2011) studied this question.