What question did this study set out to answer?

To review current developments in nanotechnology-based delivery systems for artificial microRNA therapeutics in cancer and assess prospective future strategies.

July 27, 2023Frontiers in Bioengineering and BiotechnologyOpen Access

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

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Authors

LBLuis Alberto Bravo-VázquezInstituto Tecnológico de Querétaro AMAndrea Méndez-GarcíaInstituto Tecnológico de Querétaro ARAlma L. RodríguezBrigham and Women's Hospital

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Implication

Review reveals nanotechnology-based delivery enhances microRNA therapeutic efficacy in cancer, highlighting emerging platforms like plant-derived nanoparticles and nanozymes.

Key Points

To review current developments in nanotechnology-based delivery systems for artificial microRNA therapeutics in cancer and assess prospective future strategies.
Synthesized recent literature on artificial microRNAs, including anti-miRNAs and miRNA mimics, designed to target oncogenes and tumor suppressors.
Evaluated nanoscale delivery platforms and emerging paradigms, including plant-derived nanoparticles, phytochemical-mediated miRNA modulation, and catalytic nanozymes.
Nanoscale delivery platforms circumvent physiological delivery barriers, enabling targeted delivery of microRNA mimics and inhibitors to impede cancer initiation and progression.
Novel biotechnological strategies, such as green-synthesized plant nanoparticles and nanozymes, demonstrate qualitative potential to address targeted delivery hurdles and off-target toxicity.

Cite This Study

Bravo-Vázquez et al. (2023) studied this question.

synapsesocial.com/papers/6a7223e7a528af2d65c45315 https://doi.org/10.3389/fbioe.2023.1208547

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Implication

Review reveals nanotechnology-based delivery enhances microRNA therapeutic efficacy in cancer, highlighting emerging platforms like plant-derived nanoparticles and nanozymes.

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Discussion

Member takes

Implication

Key Points

Cite This Study

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Discussion

Member takes

Implication

Key Points

Cite This Study

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