Can molecular biology and bioinformatics be used to probe an evolutionary pathway?

Williamson has proposed an interesting hypothesis regarding the evolution of caterpillars from onycophorans by hybridogenesis “as an addition to Darwin's great insight into the generation of diversity ” (1). He has proposed some molecular biology-/ bioinformatics-based experiments to test his theory of hybridogenesis. Although his theory is interesting, we think that the experiments he proposes are too simplistic and will not necessarily shed much light on the topic.