What question did this study set out to answer?

To determine whether early administration of methylprednisolone or ibuprofen reduces the severity of late-stage radiation-induced heart disease and myocardial fibrosis.

May 1, 1982Circulation

Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease.

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Why the study?

Does early administration of methylprednisolone or ibuprofen reduce myocardial fibrosis and improve survival in a rabbit model of radiation-induced heart disease?

Key Points

To determine whether early administration of methylprednisolone or ibuprofen reduces the severity of late-stage radiation-induced heart disease and myocardial fibrosis.
Evaluated 57 New Zealand white rabbits assigned to irradiated groups receiving intravenous methylprednisolone (30 mg/kg twice daily for 3 days; n=15), ibuprofen (12.5 mg/kg twice daily for 2 days; n=15), or no drug (n=14), alongside an untreated, unirradiated control cohort (n=13).
Monitored animals over a 100-day follow-up period following cardiac irradiation.
Assessed incidence of pericarditis and pericardial effusion, and quantified myocardial fibrosis via myocardial hydroxyproline concentration at 100 days.
Survival at 100 days was 100% (15/15) in methylprednisolone-treated and 86.7% (13/15) in ibuprofen-treated rabbits versus 50.0% (7/14) in untreated irradiated controls (p < 0.01 and p < 0.05, respectively).
Pericarditis (p < 0.05) and pericardial effusion (p < 0.01) occurred significantly less frequently in both drug-treated irradiated groups compared to untreated irradiated rabbits.
Myocardial hydroxyproline concentrations were significantly higher in untreated irradiated rabbits than in those treated with methylprednisolone (p < 0.05) or ibuprofen (p < 0.01).

Structured PICO

Does early administration of methylprednisolone or ibuprofen reduce myocardial fibrosis and improve survival in a rabbit model of radiation-induced heart disease?

Population

57 New Zealand white rabbits subjected to cardiac irradiation (experimental model of radiation-induced heart disease)

Intervention

Methylprednisolone (30 mg/kg i.v. twice daily for 3 days) or ibuprofen (12.5 mg/kg twice daily for 2 days) administered before and shortly after cardiac irradiation

Comparator

Untreated, irradiated rabbits (n=14) and untreated, unirradiated control rabbits (n=13)

Outcome

Myocardial hydroxyproline concentrations (MHP) as a measure of myocardial fibrosis, and survival at 100 dayssurrogate

Early administration of methylprednisolone or ibuprofen retards the development of myocardial fibrosis and improves survival in a rabbit model of radiation-induced heart disease.

Discussion

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Implication

Hypothesis-generating for anti-inflammatory agents in radiation cardiotoxicity; leaves open translation to human prevention strategies.

Cite This Study

Reeves et al. (1982) studied this question.

synapsesocial.com/papers/6a7226eb26a7f98052de27a4 https://doi.org/10.1161/01.cir.65.5.924

Topics

Pericardial disease

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Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider