Key result
Preliminary experiments were conducted in 46 rabbits to establish a reliable animal model for radiation-induced heart disease using single-dose high-energy x-irradiation.
Why the study?
Does high-energy x-irradiation induce heart lesions in a rabbit model?
Population
46 New Zealand white rabbits of both sexes, six to ten weeks old and weighing 1,500 to 2,300 g
Design
Preclinical
Authors
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Enables mechanistic studies of radiation cardiotoxicity in rabbits; does not inform clinical practice.
Does high-energy x-irradiation induce heart lesions in a rabbit model?
This study describes the methodology for establishing a rabbit model to investigate the mechanism and evolution of radiation-induced heart disease.
Stewart et al. (1968) studied Radiation-induced heart disease (n=46). High-energy x-irradiation was evaluated on Development of radiation-induced heart lesions. Preliminary experiments were conducted in 46 rabbits to establish a reliable animal model for radiation-induced heart disease using single-dose high-energy x-irradiation.
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