Why the study?
Does a single high dose of radiation (20 Gy) impair mechanical performance and alter antioxidant defenses in the rat heart?
Does a single high dose of radiation (20 Gy) impair mechanical performance and alter antioxidant defenses in the rat heart?
High-dose local heart irradiation in rats leads to chronic myocardial mechanical impairment and delayed activation of antioxidant defenses, suggesting radiation-induced heart failure.
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High-dose rat cardiac irradiation impairs output with antioxidant shifts; hypothesis-generating for human cardiotoxicity, should not change practice.
Benderitter et al. (1995) studied this question.
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