What question did this study set out to answer?

To compare in vivo cardiac function with ex vivo cardiac performance after localized thoracic irradiation in the same rat model over time.

October 1, 1997British Journal of RadiologyOpen Access

Comparison of in vivo cardiac function with ex vivo cardiac performance of the rat heart after thoracic irradiation.

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Why the study?

Does in vivo cardiac function correlate with ex vivo cardiac performance in rats after thoracic irradiation?

Key Points

To compare in vivo cardiac function with ex vivo cardiac performance after localized thoracic irradiation in the same rat model over time.
Sprague-Dawley rats received a single 20 Gy dose of local thoracic irradiation and were monitored up to 16 months post-treatment.
In vivo left ventricular ejection fraction (LVEF) was assessed using radionuclide ventriculography, followed four days later by ex vivo performance testing in an isolated working heart system.
Ex vivo stroke volume declined significantly by 4 months (p < 0.04) and cardiac output decreased significantly by 12 months (p < 0.05), with progressive decline through 16 months.
In vivo LVEF showed no significant change for 12 months, followed by a sharp decline from 65 ± 2% to 46 ± 8% at 16 months post-treatment (p < 0.01), correlating with ex vivo output only when heart failure symptoms appeared.

Structured PICO

Does in vivo cardiac function correlate with ex vivo cardiac performance in rats after thoracic irradiation?

Population

Sprague-Dawley rats

Intervention

Local heart irradiation (single dose of 20 Gy)

Outcome

Comparison of in vivo cardiac function (LVEF) and ex vivo cardiac performance (cardiac output and stroke volume)surrogate

Ex vivo cardiac performance deteriorates earlier than in vivo LVEF after thoracic irradiation in rats, suggesting in vivo compensatory mechanisms mask early radiation-induced cardiac damage.

Discussion

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Implication

Compensatory mechanisms may mask early radiation cardiotoxicity in vivo; leaves open whether ex vivo metrics improve patient monitoring.

Cite This Study

Franken et al. (1997) studied this question.

synapsesocial.com/papers/6a815b2c462be2b31d22cb50 https://doi.org/10.1259/bjr.70.838.9404203

Topics

HFrEF treatment Heart failure

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Comparison of in vivo cardiac function with ex vivo cardiac performance of the rat heart after thoracic irradiation.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Comparison of in vivo cardiac function with ex vivo cardiac performance of the rat heart after thoracic irradiation.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider