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November 1, 1992American Review of Respiratory Disease

The Transport of Albumin: A Critique of the Vesicular System in Transendothelial Transport

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Authors

CMC. C. MichelImperial College London

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Implication

Mechanistic review reveals low convective coupling for albumin escape in intact circulation, suggesting transendothelial transport occurs via transient communications within vesicular networks.

Key Points

  • To evaluate the quantitative significance and structural mechanisms of the endothelial vesicular system during transendothelial albumin transport.
  • Assessed ultrastructural and tracer data from electron-opaque tracer studies regarding single-vesicle transcytotic shuttling.
  • Compared physiological convective coupling metrics and albumin clearance rates against ferritin-labeled vesicular dynamics in perfused microvessels.
  • Ultrastructural evidence indicates that transendothelial transport of electron-opaque tracers does not support transcytotic shuttling of individual vesicles.
  • Convective coupling is low during albumin extravasation from the intact circulation, differing from high coupling in perfused tissue preparations.
  • Albumin clearance matches values calculated from vesicular ferritin labeling, indicating transport occurs through transient communications between vesicles.

Cite This Study

C. C. Michel (1992) studied this question.

synapsesocial.com/papers/6a722721f44fa9f079dfba0ahttps://doi.org/10.1164/ajrccm/146.5_pt_2.s32
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Albumin interacts specifically with a 60-kDa microvascular endothelial glycoprotein.1988 · 147 citations
  2. 2The labelling of vesicles in frog endothelial cells with ferritin.1979 · 49 citations
  3. 3Capillary transport of macromolecules: pores and other endothelial pathways1985 · 140 citations
  4. 4Transcytosis of albumin in capillary endothelium.1987 · 272 citations
  5. 5The endothelial vesicle system in cryofixed frog mesenteric capillaries analysed by ultrathin serial sectioning1991 · 39 citations