Myelosclerosis With Serosal Myeloid Metaplasia and Fatal Liver Involvement

Case Reports1 November 1960MYELOSCLEROSIS WITH SEROSAL MYELOID METAPLASIA AND FATAL LIVER INVOLVEMENTBORIS RUEBNER, M.D.BORIS RUEBNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-5-1075 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMyelosclerosis with a leuko-erythroblastic anemia and splenomegaly has become a well recognized clinical syndrome. Much controversy still surrounds its etiology, which may well be multiple.1 The present case is thought worth reporting because of the unusual situation and marked fibrosis of some of the extramedullary foci, and also because of the severity of the hepatic involvement.CASE REPORTHistory: A 67 year old night watchman of partly West Indian, partly European ancestry was first admitted to the Victoria General Hospital in 1951. He had been suffering from increasing weakness and fatigue during the preceding seven years.On physical examination the...Bibliography1. WyattSommers JPSC: Chronic marrow failure, myelosclerosis and extramedullary hematopoiesis, Blood 5: 329, 1950. CrossrefMedlineGoogle Scholar2. AzarHillOsserman HAWTEF: Malignant lymphoma and lymphatic leukemia associated with myeloma-type proteins, Am. J. Med. 23: 239, 1957. CrossrefMedlineGoogle Scholar3. CloseTairaCleveland ASYDA: Spinal cord compression due to extramedullary hematopoiesis, Ann. Int. Med. 48: 422, 1958. Google Scholar4. CauchieDenolin-ReubensDustin CRP: Hypertrophie pseudo-tumorale du mésentère dans un cas de myélosclérose, Rev. hémat. 13: 422, 1958. MedlineGoogle Scholar5. Dameshek W: Some speculations on the myeloproliferative syndromes, Blood 6: 372, 1951. CrossrefMedlineGoogle Scholar6. VaughanHarrison JMCV: Leukoerythroblastic anemia and myelosclerosis, J. Path. and Bact. 48: 339, 1939. CrossrefGoogle Scholar7. 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Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication November 19, 1958.From the Department of Pathology, Dalhousie University and Victoria General Hospital, and the Provincial Pathology Institute of Nova Scotia, Halifax, Nova Scotia, Canada.Requests for reprints should be addressed to Boris Ruebner, M.D., Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland. 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NAKAI, M.D., CHARLES G. CRADDOCK, M.D., F.A.C.P., WILLIAM G. FIGUEROA, M.D. 1 November 1960Volume 53, Issue 5Page: 1075-1088KeywordsAnemiaCirrhosisEtiologyFatigueFibrosisHypertensionLesionsLiverRegenerative medicineSplenomegaly ePublished: 1 December 2008 Issue Published: 1 November 1960 PDF downloadLoading ...