Pharmacokinetic modeling reveals serum albumin alters caspofungin clearance in heart transplant recipients, indicating lower albumin levels require higher drug doses.
) were 2.85 liters/h and 6.01 liters, respectively. In the final model, we found that albumin (ALB) affected the CL of caspofungin with an adjustment factor of -1.01, and no other covariates were identified. In this study, HTx was not found to affect the PK of caspofungin. Based on the simulations, the dose of caspofungin should be proportionately increased in patients with decreased ALB levels.
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Wu et al. (2022) studied this question.
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