What question did this study set out to answer?

To assess the single- and multiple-dose pharmacokinetics and safety profile of intravenous caspofungin in healthy adult men.

March 1, 2002Antimicrobial Agents and ChemotherapyOpen Access

Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men

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To assess the single- and multiple-dose pharmacokinetics and safety profile of intravenous caspofungin in healthy adult men.
Conducted four phase I trials using 1-hour intravenous infusions across single escalating doses (5 to 100 mg; two alternating panels of 6 men) and multiple-dose cohorts.
Evaluated daily regimens of 15, 35, and 70 mg over 2 to 3 weeks, as well as 50 mg daily with or without an initial 70 mg loading dose on day 1.
Single-dose infusions showed dose-proportional increases in plasma concentrations, a beta-phase half-life of 9 to 10 hours, clearance of 10 to 12 ml/min, and minimal renal clearance (~2% of dose).
Multiple-dose regimens demonstrated drug accumulation averaging 24% at 15 mg daily and approximately 50% at 50 and 70 mg daily, with all dosing schedules generally well tolerated.
Regimens of 70 mg daily or 50 mg daily with a 70 mg loading dose maintained mean plasma levels above the 1.0 µg/ml target throughout therapy, whereas 50 mg without a loading dose fell below target for the first 2 days.

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Implication

Phase I trials reveal dose-proportional pharmacokinetics and moderate accumulation of caspofungin in healthy men, supporting once-daily dosing regimens for fungal infections.

Cite This Study

Stone et al. (2002) studied this question.

synapsesocial.com/papers/6a865ec6a7f00d34f6739f8d https://doi.org/10.1128/aac.46.3.739-745.2002

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Implication

Phase I trials reveal dose-proportional pharmacokinetics and moderate accumulation of caspofungin in healthy men, supporting once-daily dosing regimens for fungal infections.

Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men

Key Points

Discussion

Implication

Cite This Study

Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men

Key Points

Discussion

Implication

Cite This Study

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