What question did this study set out to answer?

To develop a sample size allocation method for dose-response studies based on the precision of estimating the dose required to achieve a clinically meaningful difference compared to placebo.

January 1, 1992Journal of Biopharmaceutical Statistics

Sample size for a dose-response study

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Authors

HPH. I. PatelAT&T (United States)

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Implication

Methodological study demonstrates a sample size allocation framework for dose-response curves, suggesting improved precision in detecting clinically meaningful differences over placebo.

Key Points

To develop a sample size allocation method for dose-response studies based on the precision of estimating the dose required to achieve a clinically meaningful difference compared to placebo.
Formulated sample size calculations assuming a logistic model for the dose-response relationship.
Developed mathematical derivations primarily for binary response endpoints and extended the framework to continuous variables.
Established an allocation framework linking sample size directly to the desired estimation precision of the target effective dose over placebo.
Provided an illustrative example demonstrating the application of the methodology in clinical study design.

Cite This Study

H. I. Patel (1992) studied this question.

synapsesocial.com/papers/6a7229ce8031ec7bb1dd42f4 https://doi.org/10.1080/10543409208835027

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Implication

Methodological study demonstrates a sample size allocation framework for dose-response curves, suggesting improved precision in detecting clinically meaningful differences over placebo.

Sample size for a dose-response study

Discussion

Member takes

Implication

Key Points

Cite This Study

Sample size for a dose-response study

Discussion

Member takes

Implication

Key Points

Cite This Study

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