Why the study?
The trade-offs and challenges posed by the increasing scale and complexity of cohort studies needed exploration, addressing the premise that bigger is not always better.
This analysis argues that large-scale Chinese cohort studies must move beyond merely expanding sample size and variable diversity to adopt a clinician-initiated, hospital-integrated, value-oriented framework that prioritizes data standardization, clinical relevance, and long-term follow-up quality.
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Bigger cohort studies are not always better; leaves open optimal designs balancing scale with quality in cardiovascular research.
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Lin et al. (2025) studied this question.
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