What question did this study set out to answer?

To determine the contribution of the CXC chemokines IP-10 and Mig to the antitumor and vascular-damaging effects elicited by interleukin-12.

September 1, 1998Journal of Leukocyte Biology

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

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To determine the contribution of the CXC chemokines IP-10 and Mig to the antitumor and vascular-damaging effects elicited by interleukin-12.
Treated athymic mouse tumor models with local inoculations of interleukin-12, IP-10, or Mig, along with systemic interleukin-12 administration.
Assessed tumor necrosis, vascular damage, and tissue-level expression of interferon-gamma, IP-10, and Mig genes and proteins across tumor, liver, and kidney tissues.
Administered neutralizing antibodies against IP-10 and Mig in vivo to evaluate their requirement in local interleukin-12-induced antitumor responses.
Local interleukin-12 inoculation caused substantial tumor regression accompanied by necrosis and vascular damage indistinguishable from direct IP-10 or Mig treatment.
Interleukin-12 stimulated significant interferon-gamma, IP-10, and Mig expression, with chemokine levels in the tumor, liver, and kidney showing an inverse correlation with tumor size.
In vivo neutralization of IP-10 and Mig substantially impaired the antitumor efficacy of locally administered interleukin-12.

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Implication

Experimental mouse study demonstrates that chemokines IP-10 and Mig mediate interleukin-12 tumor suppression in athymic mice, indicating an essential vascular disruption mechanism.

Cite This Study

Kanegane et al. (1998) studied this question.

synapsesocial.com/papers/6a722b31c1a24a6142dbcf13 https://doi.org/10.1002/jlb.64.3.384

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Implication

Experimental mouse study demonstrates that chemokines IP-10 and Mig mediate interleukin-12 tumor suppression in athymic mice, indicating an essential vascular disruption mechanism.

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

Key Points

Discussion

Implication

Cite This Study

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

Key Points

Discussion

Implication

Cite This Study

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