Population
Human rhinovirus 14 (HRV14) and monoclonal antibody mAb17-IA complex
Comparison
Cryo-electron microscopy and image reconstruction vs Native HRV14 virions and Fab-virus complex
Design
Preclinical
Authors
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Supports steric or stabilizing neutralization without capsid rearrangement; hypothesis-generating for antibody design, leaves open human translation.
Bivalently bound IgGs do not cause gross deformations in the HRV14 capsid, suggesting antibody-mediated neutralization occurs via steric blockage or capsid stabilization rather than large structural rearrangements.
Smith et al. (1993) studied this question.
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