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December 1, 1983The Journal of Organic Chemistry

A reagent for introducing the phosphinic acid isostere of phosphodiesters

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Authors

LVLuís VargasUniversity of GuayaquilARArthur RosenthalQueens College, CUNY

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Implication

Laboratory study demonstrates synthesis of a reagent to introduce phosphinic acid isosteres into phosphodiesters, suggesting routes to stable biomolecules.

Key Points

  • To develop and evaluate a specialized chemical reagent designed to introduce a phosphinic acid isosteric replacement for phosphodiester linkages.
  • Synthesized a novel phosphorus-based chemical reagent tailored for organic functionalization.
  • Applied the reagent to prepare phosphinic acid analogs mimicking biological phosphodiester bonds.
  • Enabled direct chemical introduction of the phosphinic acid moiety as a stable phosphodiester surrogate without quantitative yield data reported.
  • Provided a synthetic methodology to generate hydrolytically resistant biomimetic phosphorus compounds.

Cite This Study

Vargas et al. (1983) studied this question.

synapsesocial.com/papers/6a722caab27f15817827f63ehttps://doi.org/10.1021/jo00172a065
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