What question did this study set out to answer?

To synthesize deoxyribonucleoside-3′,5′ cyclic phosphates and characterize their degradation pathways under acid-catalyzed and enzymic hydrolysis conditions.

April 1, 1964Journal of the American Chemical Society

Deoxyribonucleoside-3′,5′ Cyclic Phosphates. Synthesis and Acid-Catalyzed and Enzymic Hydrolysis

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Authors

GDGeorge I. DrummondAlbert Einstein College of Medicine MGMichael W. GilganFisheries and Oceans Canada ERElsa ReinerInstitute for Medical Research and Occupational Health

Discussion

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Implication

Biochemical analysis reveals the synthesis and degradation of deoxyribonucleoside cyclic phosphates under acidic and enzymatic conditions, indicating key mechanisms of nucleotide stability.

Key Points

To synthesize deoxyribonucleoside-3′,5′ cyclic phosphates and characterize their degradation pathways under acid-catalyzed and enzymic hydrolysis conditions.
Synthesized deoxyribonucleoside-3′,5′ cyclic phosphate chemical derivatives.
Assessed stability and reaction kinetics under acid-catalyzed hydrolytic conditions.
Evaluated substrate reactivity and cleavage patterns in the presence of hydrolytic enzymes.
Deoxyribonucleoside-3′,5′ cyclic phosphate derivatives were successfully synthesized and isolated.
Susceptibility and mechanistic cleavage profiles under acid catalysis and enzymic hydrolysis were characterized.

Cite This Study

Drummond et al. (1964) studied this question.

synapsesocial.com/papers/6a7cf71cff0bedc5b12fa913 https://doi.org/10.1021/ja01062a036

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April 1, 1964Journal of the American Chemical Society

Deoxyribonucleoside-3′,5′ Cyclic Phosphates. Synthesis and Acid-Catalyzed and Enzymic Hydrolysis

View Full Paper

Ask AI

Bookmark

Authors

GDGeorge I. DrummondAlbert Einstein College of Medicine MGMichael W. GilganFisheries and Oceans Canada ERElsa ReinerInstitute for Medical Research and Occupational Health

Discussion

Member takes

Implication

Biochemical analysis reveals the synthesis and degradation of deoxyribonucleoside cyclic phosphates under acidic and enzymatic conditions, indicating key mechanisms of nucleotide stability.

Key Points

To synthesize deoxyribonucleoside-3′,5′ cyclic phosphates and characterize their degradation pathways under acid-catalyzed and enzymic hydrolysis conditions.
Synthesized deoxyribonucleoside-3′,5′ cyclic phosphate chemical derivatives.
Assessed stability and reaction kinetics under acid-catalyzed hydrolytic conditions.
Evaluated substrate reactivity and cleavage patterns in the presence of hydrolytic enzymes.
Deoxyribonucleoside-3′,5′ cyclic phosphate derivatives were successfully synthesized and isolated.
Susceptibility and mechanistic cleavage profiles under acid catalysis and enzymic hydrolysis were characterized.

Cite This Study

Drummond et al. (1964) studied this question.

synapsesocial.com/papers/6a7cf71cff0bedc5b12fa913 https://doi.org/10.1021/ja01062a036

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