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Yeast have many genes with homologs in humans. Has our understanding of these genes helped our understanding of human biology or disease? In his Perspective, Botstein argues yes and, as an example, discusses a report in this week9s issue by Sinclair et al. on the yeast homolog of the gene whose dysfunction causes a disease of premature aging, Werner syndrome.
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Botstein et al. (1997) studied this question.
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