This article reviews the immunophysiology of polio infection and the immunological response following natural infection or oral polio vaccine immunization, with a focus on the challenges in Nigeria and sub-Saharan Africa.
Informs polio control strategies in endemic African regions; leaves open optimization of vaccine responses in high-burden settings.
Poliomyelitis has been ravaging many developing countries especially those in sub-Sahara Africa. The cumulated number of children with wild poliovirus recorded has been increasing astronomically especially in Africa continent and particularly in Nigeria. This article reviews the immunophysiology of infection; and immunological response in serum and secretions following natural infection or immunization with oral polio vaccine. Nigerian Medical Practitioner Vol.46(3) 2004: 50-55
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Abdulraheem et al. (2004) studied this question.
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