Why the study?
Does aspirin reduce perinatal death and preeclampsia in women with historical risk factors?
Population
14 randomized trials including 12,416 women with predisposing historical risk factors
Comparison
Aspirin vs Placebo or no treatment
Design
Meta-analysis
Authors
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Supports aspirin prophylaxis in at-risk pregnancies; reinforces Level 1 evidence for perinatal benefit.
Does aspirin reduce perinatal death and preeclampsia in women with historical risk factors?
Aspirin therapy significantly reduces the risk of perinatal death and preeclampsia in women with historical risk factors, without increasing the risk of placental abruption.
Arri Coomarasamy (2003) studied this question.
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