Why the study?
The study was conducted to compare the efficacy of intravenous dexmedetomidine versus butorphanol for balanced anaesthesia and postoperative analgesia in patients undergoing laparoscopic surgery under general anaesthesia.
Does dexmedetomidine compared to butorphanol improve hemodynamics and postoperative analgesia in adults undergoing laparoscopic surgery?
Does dexmedetomidine compared to butorphanol improve hemodynamics and postoperative analgesia in adults undergoing laparoscopic surgery?
Intravenous butorphanol provides superior hemodynamic stability during intubation and pneumoperitoneum, as well as longer postoperative analgesia, compared to dexmedetomidine in laparoscopic surgery.
May support either agent for laparoscopic anaesthesia; leaves open need for RCTs to guide practice.
To compare efficacy of intravenous dexmedetomidine versus butorphanol for balanced anaesthesia and postoperative analgesia in patients undergoing laparoscopic surgery under general anaesthesia. After obtaining institutional ethical committee approval & written informed consent 54 adults of either gender aged 18-60 years, of grade I & II ASA were divided into two equal groups; Group D received Inj. Dexmedetomidine 1 µg/kg i.v. & Group B, Inj. Butorphanol 10 µg/kg i.v., in 100ml NS over 10 minutes before induction. Standard general anaesthesia technique including propofol, succinylcholine/Atracurium, IPPV & Isoflurane/N20 was administered. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) & SPO2 were recorded at - baseline, after-drug administration, induction, at intubation & 1, 3 & 5 minutes after intubation, at pneumoperitoneum & 15 minutes intervals upto 30 minutes after extubation. Postoperative Visual Analog Scale (VAS) Scores & Ramsay Sedation Score (RSS) were evaluated half hourly till score of >4 & <2 were recorded, respectively.
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Thomas et al. (2022) studied this question.
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