Key result
Dexmedetomidine fails to reduce intraoperative narcotic consumption compared to lidocaine during open abdominal surgery.
Why the study?
Intravenous dexmedetomidine and lidocaine have been shown to decrease perioperative surgical pain and analgesic consumption and facilitate recovery after abdominal surgery, but their comparative effects are unclear.
Does intravenous dexmedetomidine compared to lidocaine improve post-operative analgesia and reduce narcotic consumption in patients undergoing abdominal surgery?
RCT (n=140)
Double-blind
Computer-generated random sequences
No
Does intravenous dexmedetomidine compared to lidocaine improve post-operative analgesia and reduce narcotic consumption in patients undergoing abdominal surgery?
Absolute Event Rate: 229.71% vs 229.57%
p-value: p=0.964
Lidocaine and dexmedetomidine provide similar post-operative analgesia after abdominal surgery, but lidocaine is associated with better intraoperative hemodynamic stability and fewer post-operative side effects such as nausea and vomiting.
No difference in narcotic use between dexmedetomidine and lidocaine; leaves open their comparative value versus placebo or standard care in abdominal surgery.
Background Intravenous dexmedetomidine and lidocaine have been shown to decrease perioperative surgical pain and analgesic consumption and facilitate the return of bowel function, decreasing post-operative hospitalization. Results On the first post-operative day, VAS score and total consumption of narcotics were statistically insignificant between the two groups. Heart rate and mean arterial pressure were significantly lower in the dexmedetomidine group than in the Lidocaine group all through the surgery (p value < 0.001). Post-operative nausea and vomiting were statistically higher in group D than in group L (p value 0.001). Conclusions The administration of either lidocaine or dexmedetomidine did not show superiority in post-operative analgesia or perioperative narcotics consumption. However, lidocaine infusion showed less drug-related side effects from the aspect of intraoperative hemodynamics stability, post-operative ileus, nausea, and vomiting.
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Ibrahim et al. (2022) conducted an RCT in Elective open abdominal surgery (n=140). Dexmedetomidine vs. Lidocaine (1.5 mg/kg loading dose over 5 min, followed by 1 mg/kg/h) was evaluated on Total intraoperative consumption of narcotics (μg) (p=0.964). Intravenous infusion of dexmedetomidine did not significantly differ from lidocaine in total intraoperative narcotic consumption (229.71 vs 229.57 μg, p=0.964) during elective open abdominal surgery.
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