September 13, 2007Onderstepoort Journal of Veterinary ResearchOpen Access

Study of the genetic heterogeneity of SAT-2 foot-and-mouth disease virus in sub-Saharan Africa with specific focus on East Africa

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Population

67 SAT-2 foot-and-mouth disease virus isolates from sub-Saharan Africa

Design

Preclinical

Authors

MSMesfin SahleUniversity of Debrecen RDRahana DwarkaOnderstepoort Veterinary Institute EVEstelle H. VenterNational Health Laboratory Service

Discussion

Member takes

Implication

SAT-2 FMDV diversity may undermine vaccination efficacy in East Africa; leaves open needs for updated multivalent vaccines.

Structured PICO

Population

67 SAT-2 foot-and-mouth disease virus isolates from sub-Saharan Africa (41 newly sequenced from East Africa, 26 previously published)

Intervention

Phylogenetic analysis using the 1D gene encoding the major antigenic determinant

Outcome

Genetic heterogeneity and phylogenetic relationships (genotypes and lineages)

The high genetic variation and identification of novel genotypes of SAT-2 FMD virus in East Africa highlight significant challenges for disease control using vaccination.

Cite This Study

Sahle et al. (2007) studied this question.

synapsesocial.com/papers/6a7231ee2163a0a01bc5fbc2 https://doi.org/10.4102/ojvr.v74i4.115

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Study of the genetic heterogeneity of SAT-2 foot-and-mouth disease virus in sub-Saharan Africa with specific focus on East Africa

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Study of the genetic heterogeneity of SAT-2 foot-and-mouth disease virus in sub-Saharan Africa with specific focus on East Africa

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider