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November 8, 2004Onderstepoort Journal of Veterinary ResearchOpen Access

Molecular epidemiology of serotype O foot-and-mouth disease virus isolated from cattle in Ethiopia between 1979-2001

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Population

36 serotype O foot-and-mouth disease viruses, including 17 isolated from cattle in Ethiopia between…

Design

Preclinical

Authors

MSMesfin SahleUniversity of DebrecenEVEstelle H. VenterNational Health Laboratory ServiceRDRahana DwarkaOnderstepoort Veterinary Institute

Discussion

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Overview

Divergence from the vaccine strain may compromise protection in Ethiopian livestock; leaves open whether topotype I-specific vaccines are needed.

Structured PICO

P
Population
36 serotype O foot-and-mouth disease (FMD) viruses, including 17 isolated from cattle in Ethiopia between 1979-2001, and 19 other isolates from Eritrea, Kenya, South and West Africa, the Middle East, Asia, and South America.
I
Intervention
Partial 1D gene characterization and phylogenetic analysis
O
Outcome
Phylogenetic relationships and amino acid variability at immunodominant sites

Ethiopian serotype O FMD viruses exhibit significant genetic and amino acid heterogeneity compared to the currently used vaccine strain, highlighting the need for vaccine reassessment.

Cite This Study

Sahle et al. (2004) studied this question.

synapsesocial.com/papers/6a7231ee2163a0a01bc5fbc3https://doi.org/10.4102/ojvr.v71i2.275
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Also Consider

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  1. 1Molecular epidemiology of foot-and-mouth disease virus type O1993 · 50 citations
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  4. 4Systematic Replacement of Amino Acid Residues within an Arg-Gly-Asp-containing Loop of Foot-and-Mouth Disease Virus and Effect on Cell Recognition1996 · 129 citations
  5. 5Rapid and simple method for purification of nucleic acids1990 · 5,322 citations