Causal effects of office-associated behaviors on spinal stenosis: Two-sample Mendelian randomization study

Figures

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  Figure 1.. The train of thought diagram of Mendelian stochastic analysis.

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  Figure 2.. SNP filtered by the P-value < 5E−08 standard, visualized and analyzed, represented by a circle chart. (A) Sitting height; (B) nap during day; and (C) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 3.. SNP filtered by the P-value < 5E−08 standard, visually analyzed, represented by a Manhattan map. (A) Sitting height; (B) nap during day; and (C) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 4.. In the forest chart, the relationship between SNP distribution and spinal stenosis, >0 is a risk factor, and <0 is an insurance factor. (A) Sitting height; (B) nap during day; and (C) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 5.. The relationship between SNP distribution and spinal stenosis was >0 as a risk factor and <0 as an insurance factor. (A) Sitting height; (B) nap during day; and (C) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 6.. Funnel plot, the SNP distribution was checked by inverse variance weighted and MR Egger, and the SNP distribution of both methods was uniform, indicating low heterogeneity. (A) Sitting height; (B) nap during day; and (C) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 7.. Scatter plot, analysis of SNP and disease risk by IMR Egger, weighted median, inverse variance weighted, simple mode, and weighted mode. When the curves of the 5 methods are consistent upward, it suggests that the exposure factor is a risk factor for disease. When the 5 method curves are consistent downward, the exposure factor is an insurance factor for the disease. (A) Sitting height; (B) nap during day; and (C) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 8.. Forest plot, analysis of SNPs and disease risk by IMR Egger, weighted median, inverse variance weighted, simple mode, and weighted mode. P < .05 was considered statistically significant. An OR value > 1 indicates a risk factor, and an OR value <1 indicates an insurance factor. (A) Sitting height; (B) BMI. BMI = body mass index, SNP = single nucleotide polymorphisms.

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  Figure 9.. Second Mendelian randomization analysis of positive samples. (A) Sitting height is a protective factor for spinal stenosis, and (B) BMI is a risk factor for spinal stenosis. P < .05 was considered statistically significant. An OR value > 1 indicates a risk factor, and an OR value <1 indicates an insurance factor. BMI = body mass index.