Synthesis, characterization, and antibacterial activities of some metal complexes of heptadentate schiff base ligand derived from acetylacetone

The preparation and characterization of Fe(III), Ni(II), and Mn(III) complexes of tripodalheptadentate Schiff-base ligand N[CH 2 CH 2 N=C(Me)CH=C(Me)OH] 3 have been studied. Heptadentate Schiff base ligand was derived from acetylacetone and tris(2-aminoethyl)amine. These compounds have been characterized by elemental analysis, 1 H NMR, 13 C NMR, IR, and UV–VIS spectroscopy techniques. This is the first study which investigates the antibacterial activity of heptadentate (N 4 O 3 ) Schiff base ligand namely tris[(4-hydroxypentenylidene- 2-imino)ethyl]amine and its complexes. The in vitro biological screening effects of the investigated compounds were tested against the Gram-negative bacteria; Escherichia coli, Pseudomonas aeruginosa and Gram-positive bacteria; Staphylococcus aureus, Bacillus cereus by the disc diffusion and micro-broth dilution methods. All the compounds have shown potent antibacterial activity compared to the standards. The metal complexes were shown to possess more antibacterial activity than the uncomplexed Schiff base.