October 2, 2017PLoS Computational BiologyOpen Access

A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation

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Structured PICO

Population

Computational multi-scale continuum-mechanical skeletal muscle model (generic cubic muscle specimen with initial edge length L0 = 1cm)

Intervention

Inclusion of actin-titin interactions in the model (models MFv ATI and MATI)

Comparator

Models omitting actin-titin interactions (models MFv and Mxx)

Outcome

Prediction of stable contractions, accurate forces, and homogeneous half-sarcomere lengths on the descending limb of the force-length relation

Discussion

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Implication

Including actin-titin interactions in a continuum-mechanical skeletal muscle model predicts stable contractions and prevents non-physiological half-sarcomere length inhomogeneities on the descending limb of the force-length relation.

Cite This Study

Heidlauf et al. (2017) studied this question.

synapsesocial.com/papers/6a72350635aa2c282ce322f3 https://doi.org/10.1371/journal.pcbi.1005773

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A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation

Structured PICO

Discussion

Implication

Cite This Study

A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider